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Hemical and molecular biologic analysis was performed. Results: in prmrls, mdm2 and cdk4 stained slides were positive in 65% and 80% respectively and both tests were negative in all extremity mrls. Translocation analysis showed fus-chop or ews-chop fusion to be present in all extremity mrls, but absent in all sixteen investigated prmrls. Multiplex ligation-dependant probe amplification showed amplification of region 12q13-15 in 94% of prmls and in 5% of primary extremity mrls patients. Conclusions: classic mrls, characterized by a fus-chop or ews- chop fusion oncogen was not found in prmrls, while mdm2 and cdk4 amplification was present in most specimens. In prmrls, the probability of focal mrls-like changes in well- or de-differentiated liposarcoma is a more presumable explanation for the histologic appearance. In these cases most likely treatment should be designed as for well- or de-differentiated liposarcoma.   associated presentation(s):      1. Primary retroperitoneal myxoid liposarcomaunknown&em;unknowna non existing disease? An immunohistochemical and molecular biologic analysis. Meeting: 2008 asco annual meeting presenter: ronald s de vreeze session: sarcoma (general poster session)   other abstracts in this sub-category:      1. Detection of β-catenin mutations in primary extra-abdominal fibromatosis (eaf): an ancillary diagnostic tool. Meeting: 2008 asco annual meeting   abstract no: 10518   first author: j. Dã´mont category: sarcoma - other: sarcoma      2. Gemcitabine for previously treated aids-related kaposi's sarcoma: the western kenya experience. Meeting: 2008 asco annual meeting   abstract no: 10566   first author: k. M. Gregory category: sarcoma - other: sarcoma      3. Efficacy of methotrexate + vinblastine in intra-abdominal desmoid (mesenteric aggressive fibromatosis): retrospective analysis of 29 patients from a single institution. Meeting: 2008 asco annual meeting   abstract no: 10567   first author: p. Dileo category: sarcoma - other: sarcoma      more...   abstracts by r. S. De vreeze :      1. Multifocal myxoid liposarcoma: metastasis or second primary? A molecular biological analysis. Meeting: 2009 asco annual meeting   abstract no: 10576   first author: r. S. De vreeze category: sarcoma - soft tissue      2. Primary retroperitoneal myxoid liposarcomaunknown&em;unknowna non existing disease? buy viagra on line buy cheap viagra viagra cheap buy canada generic viagra viagra for sale us http://medicaresupplementspecialists.com/pfz-sale-viagra-rp/ cheap generic viagra india viagra for sale viagra without a doctor prescription viagra without a doctor prescription An immunohistochemical and molecular biologic analysis. Meeting: 2008 asco annual meeting   abstract no: 10569   first author: r. S. De vreeze category: sarcoma - other: sarcoma      more...   presentations by r. S. De vreeze :      1. Multifocal myxoid liposarcoma: metastasis or second primary? A molecular biological analysis. Meeting: 2009 asco annual meeting presenter: ronald s de vreeze, md session: sarcoma (general poster session)      2. Primary retroperitoneal myxoid liposarcomaunknown&em;unknowna non existing disease? An immunohistochemical and molecular biologic analysis. Meeting: 2008 asco annual mee.
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