hub sciencedirect scopus applications register login login go to scival suite username: password: remember me | not registered? Forgotten your username or password? Go to athens / institution login remote access activation home publications search my settings my alerts shopping cart help export citation purchase more options... where to buy viagra generic viagra no doctor prescriptions buy viagra generic viagra by mail cheapest viagra generic viagra online cheapest viagra online pharmacy india generic viagra online pharmacy generic viagra by mail Email article signed up for journal alerts [remove] alert me about new articles in this journal your selection(s) could not be saved due to an internal error. Please try again. Search     all fields     author advanced search     journal/book title     volume   issue   page search tips article outline is loading... Javascript required for article outline joint bone spine volume 69, issue 6, december 2002, pages 538–545 review diagnostic tools for amyloidosis eric hachulla 1 , , , gilles grateau 2 1 internal medicine department, centre hospitalier régional et universitaire, hôpital claude huriez, 59037, lille cedex, france 2 internal medicine department, hôtel dieu, 1 place du parvis notre dame, 75181, paris cedex 04, france received 25 april 2002 revised 3 july 2002 accepted 3 july 2002 available online 2 april 2003 how to cite or link using doi permissions & reprints view full text purchase $31. 50 histological diagnosis determining the sites and extent of involvement sap component scintigraphy: a diagnostic and prognostic tool conclusion references abstract demonstration of amyloid deposits in biopsy specimens is the only means of confirming the diagnosis of amyloidosis. In experienced hands, nonsurgical biopsies of the rectal mucosa or, preferably, of the abdominal fat pad or labial salivary glands provide the diagnosis in 80 to 85% of cases. Immunolabeling studies help to determine the histological type of amyloidosis but are not performed routinely in everyday practice. In patients with a family history of amyloidosis, studies of the genome and amyloid protein can identify the protein variants capable of causing systemic amyloidosis. Once the diagnosis of amyloidosis is established, the extent of systemic involvement with amyloid should be evaluated by performing renal and hepatic function tests, a proteinuria assay, and an echocardiogram. Scintigraphy with radiolabeled serum amyloid p (sap) component is a rapid and specific investigation that provides a map of the amyloid deposits. Deposits are usually seen in the liver and spleen. Sap component scintigraphy can provide support for. madison smith


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